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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-11-27
pubmed:abstractText
Laryngeal dysplasia is a common clinical concern. Despite major advancements, a significant number of patients with this condition progress to invasive squamous cell carcinoma. Osteopontin (OPN) is a secreted glycoprotein, whose expression is markedly elevated in several types of cancers. We explored OPN as a candidate biomarker for laryngeal dysplasia. To this aim, we examined OPN expression in 82 cases of dysplasia and in hyperplastic and normal tissue samples. OPN expression was elevated in all severe dysplasia samples, but not hyperplastic samples, with respect to matched normal mucosa. OPN expression levels correlated positively with degree of dysplasia (P=0.0094) and negatively with disease-free survival (P<0.0001). OPN expression was paralleled by cell surface reactivity for CD44v6, an OPN functional receptor. CD44v6 expression correlated negatively with disease-free survival, as well (P=0.0007). Taken as a whole, our finding identify OPN and CD44v6 as predictive markers of recurrence or aggressiveness in laryngeal intraepithelial neoplasia, and overall, point out an important signalling complex in the evolution of laryngeal dysplasia.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-10907809, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-11595705, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-11825687, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-11929952, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-11936266, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12124327, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12213734, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12511867, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12579537, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12640447, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12748184, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12842083, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-12973674, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-14631180, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-15093538, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-15138464, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-15161704, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-15516973, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-15640281, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-15655247, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-1573667, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-15998773, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-16166420, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-16299231, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-16406521, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-16644882, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-16832409, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-16849558, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-16917865, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-2188735, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-3760239, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-7867006, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-8402617, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-8417385, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-9625170, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-9738803, http://linkedlifedata.com/resource/pubmed/commentcorrection/17987038-9811462
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1545-51
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
OPN/CD44v6 overexpression in laryngeal dysplasia and correlation with clinical outcome.
pubmed:affiliation
Dipartimento di Scienze Biomorfologiche e Funzionali, Università di Napoli Federico II, Naples, Italy.
pubmed:publicationType
Journal Article
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