Linked Life Data

17986575

Source:http://linkedlifedata.com/resource/pubmed/id/17986575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-7
pubmed:abstractText
Telomerase maintains telomeres to preclude cell senescence. It remains elusive how telomerase activity is repressed in differentiated cells, but retained at high levels in stem cells and cancer. Recent studies suggest that the Ets transcription factor family, downstream of the mitogen signaling pathways of MAP kinase, regulates telomerase activity at the gene transcription level of human telomerase reverse transcriptase (hTERT). Several Ets transcription factors are involved in regulating hTERT gene expression, both directly and indirectly through the proto-oncogene c-myc. ER81 may mediate telomerase activation in telomerase-negative fibroblasts stimulated by oncogenes Her2/Neu, Ras, and Raf. Ets2 may also play an important role in regulating the hTERT gene; but further studies are required to decipher the mechanisms in the regulation of telomerase activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-47
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family.
pubmed:affiliation
Department of Immunology, Monash University, Melbourne, Victoria, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't