Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-7
pubmed:abstractText
The largest subgroup of integrins is that containing the beta1 subunit. beta1 integrins have been implicated in a wide array of biological processes ranging from adhesion to cell growth, organogenesis, and mechanotransduction. Global deletion of beta1 integrin expression results in embryonic death at ca. embryonic day 5 (E5), a developmental time point too early to determine the effects of this integrin on vascular development. To elucidate the specific role of beta1 integrin in the vasculature, we conditionally deleted the beta1 gene in the endothelium. Homozygous deletion of beta1 integrins in the endothelium resulted in failure of normal vascular patterning, severe fetal growth retardation, and embryonic death at E9.5 to 10, although there were no overt effects on vasculogenesis. Heterozygous endothelial beta1 gene deletion did not diminish fetal or postnatal survival, but it reduced beta1 subunit expression in endothelial cells from adult mice by approximately 40%. These mice demonstrated abnormal vascular remodeling in response to experimentally altered in vivo blood flow and diminished vascularization in healing wounds. These data demonstrate that endothelial expression of beta1 integrin is required for developmental vascular patterning and that endothelial beta1 gene dosing has significant functional effects on vascular remodeling in the adult. Understanding how beta1 integrin expression is modulated may have significant clinical importance.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-10629031, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-10681423, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-10751360, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-10807272, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-11161575, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-11516395, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-11741838, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-11786413, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-11854171, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-11884376, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-11959837, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-12032352, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-12205444, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-12213443, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-12415262, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-12668602, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-12676815, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-1280276, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-14967734, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-15340074, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-15542432, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-16258728, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-16529735, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-16818815, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-17043243, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-17085437, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-7504677, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-7508365, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-7533171, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-7544312, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-7813611, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-8666584, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-8951069, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-9314545, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-9359872, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-9466966, http://linkedlifedata.com/resource/pubmed/commentcorrection/17984225-9687507
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1098-5549
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
794-802
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling.
pubmed:affiliation
BCMM 436C, 295 Congress Ave., New Haven, CT 06510, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural