Linked Life Data

1798393

Source:http://linkedlifedata.com/resource/pubmed/id/1798393

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-4-15
pubmed:abstractText
A method for the noninvasive, quantitative determination of regional cerebral blood flow (rCBF) in small laboratory animals, such as the rat, is described. The change in magnetic susceptibility in the vicinity of brain capillaries evoked by iv infusion of Gd(DTPA), a paramagnetic agent not crossing the blood-brain barrier, is detected as an attenuation of the 1H signal in T2-weighted MRI sequences. The reduction of the MR signal intensity after 1 or 2 min of Gd(DTPA) infusion correlates well (r greater than 0.95) with the rCBF values obtained using the well-established [14C]iodoantipyrine method. At a slice thickness of 3 mm, the pixel size typically is 0.15 x 0.5 mm2. The clearance rate of Gd(DTPA) from blood allows repeated measurements of CBF to be made using this technique approximately every 30 min. The experimental results obtained in normal and ischemic rat brain have been rationalized within the frame of a two-compartment model, allowing the definition of optimal experimental conditions for a given CBF: for normal and reduced CBF values (less than 150 ml/100 g/min) the reduction in MR signal intensity, measured after 1 or 2 min of Gd (DTPA) infusion, correlates closely with the CBF. However, for CBF values greater than 150 ml/100 g/min, a more reliable parameter would be the time constant of the MR signal attenuation during the infusion.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-46
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Noninvasive determination of regional cerebral blood flow in rats using dynamic imaging with Gd(DTPA)
pubmed:affiliation
Preclinical Research, Sandoz Pharma Ltd, Basel, Switzerland.
pubmed:publicationType
Journal Article