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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-11-6
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pubmed:abstractText |
Obesity-induced insulin resistance is a major factor in the etiology of type 2 diabetes, and Jun kinases (JNKs) are key negative regulators of insulin sensitivity in the obese state. Activation of JNKs (mainly JNK1) in insulin target cells results in phosphorylation of insulin receptor substrates (IRSs) at serine and threonine residues that inhibit insulin signaling. JNK1 activation is also required for accumulation of visceral fat. Here we used reciprocal adoptive transfer experiments to determine whether JNK1 in myeloid cells, such as macrophages, also contributes to insulin resistance and central adiposity. Our results show that deletion of Jnk1 in the nonhematopoietic compartment protects mice from high-fat diet (HFD)-induced insulin resistance, in part through decreased adiposity. By contrast, Jnk1 removal from hematopoietic cells has no effect on adiposity but confers protection against HFD-induced insulin resistance by decreasing obesity-induced inflammation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1550-4131
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pubmed:author |
pubmed-author:BandyopadhyayGautam KGK,
pubmed-author:GrivennikovSergeiS,
pubmed-author:KarinMichaelM,
pubmed-author:LuoJun-LiJL,
pubmed-author:NauglerWillscottW,
pubmed-author:NeelsJaap GJG,
pubmed-author:OlefskyJerrold MJM,
pubmed-author:ScadengMiriamM,
pubmed-author:SolinasGiovanniG,
pubmed-author:VilcuCristianC,
pubmed-author:Wynshaw-BorisAnthonyA
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
386-97
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pubmed:dateRevised |
2011-6-14
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pubmed:meshHeading |
pubmed-meshheading:17983584-Animals,
pubmed-meshheading:17983584-Cells, Cultured,
pubmed-meshheading:17983584-Cytokines,
pubmed-meshheading:17983584-Dietary Fats,
pubmed-meshheading:17983584-Energy Metabolism,
pubmed-meshheading:17983584-Flow Cytometry,
pubmed-meshheading:17983584-Hematopoietic Stem Cells,
pubmed-meshheading:17983584-Inflammation,
pubmed-meshheading:17983584-Insulin Resistance,
pubmed-meshheading:17983584-Interleukin-6,
pubmed-meshheading:17983584-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:17983584-Macrophages,
pubmed-meshheading:17983584-Magnetic Resonance Imaging,
pubmed-meshheading:17983584-Mice,
pubmed-meshheading:17983584-Mice, Inbred C57BL,
pubmed-meshheading:17983584-Mice, Knockout,
pubmed-meshheading:17983584-Models, Biological,
pubmed-meshheading:17983584-Obesity,
pubmed-meshheading:17983584-Palmitates,
pubmed-meshheading:17983584-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.
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pubmed:affiliation |
Department of Medicine, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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