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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-6
pubmed:abstractText
Natural Killer (NK) cells are cells of the innate immune system with characteristic effector functions, including recognition and lysis of virus-infected or tumor cells and production of immunoregulatory cytokines, particularly interferon-gamma (IFN-gamma). NK cells account for between 10 and 15% of peripheral blood lymphocytes and are also present in synovial fluid and tissue where they might potentially contribute to amplification of the inflammatory process through interactions with macrophages and dendritic cells. This chapter outlines methods of assessing the phenotype of NK cells through analysis of NK-cell markers and the function of NK cells through cytotoxicity assays and measurement of cytokine production.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1543-1894
pubmed:author
pubmed:issnType
Print
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-63
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Phenotypic and functional analysis of synovial natural killer cells.
pubmed:affiliation
Department of Immunology, Imperial College London, Hammersmith Hospital Campus, UK.
pubmed:publicationType
Journal Article