Source:http://linkedlifedata.com/resource/pubmed/id/17982100
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2007-11-5
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pubmed:abstractText |
B cells play a pathogenic or regulatory role in many autoimmune diseases through production of autoantibodies, cytokine production, and Ag presentation. However, the mechanisms that regulate these B cell functions under different autoimmune settings remain unclear. In the current study, we found that when B cells overexpress an antiapoptotic gene, Bcl(XL), they significantly increased production of IFN-gamma and enhanced Th1 response. Consistently, Bcl-x(L) transgenic mice developed more severe and sustained collagen-induced arthritis due to the enhanced Th1 response. The production of autoantibodies in Bcl(XL) transgenic mice was comparable to that in wild-type mice. Thus, our results indicate a novel role of Bcl(XL) in regulating B cell functions and immune responses. In patients with rheumatoid arthritis, arthritogenic B cells often up-regulate Bcl(XL) expression, which may not only render B cells resistant to apoptosis but also alter the ability of the autoreactive B cells to produce cytokines and modulate the inflammatory response. This may have therapeutic implications if Bcl(XL) expression can be down-regulated in autoreactive B cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7087-92
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17982100-Animals,
pubmed-meshheading:17982100-Antibody Formation,
pubmed-meshheading:17982100-Arthritis, Experimental,
pubmed-meshheading:17982100-Autoantibodies,
pubmed-meshheading:17982100-B-Lymphocytes,
pubmed-meshheading:17982100-Humans,
pubmed-meshheading:17982100-Inflammation,
pubmed-meshheading:17982100-Interferon-gamma,
pubmed-meshheading:17982100-Mice,
pubmed-meshheading:17982100-Mice, Transgenic,
pubmed-meshheading:17982100-Th1 Cells,
pubmed-meshheading:17982100-bcl-X Protein
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pubmed:year |
2007
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pubmed:articleTitle |
Overexpression of Bcl(XL) in B cells promotes Th1 response and exacerbates collagen-induced arthritis.
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pubmed:affiliation |
Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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