Linked Life Data

17981721

Source:http://linkedlifedata.com/resource/pubmed/id/17981721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-5
pubmed:abstractText
Neutrophils are the first to be recruited to a site of infection or a diseased site. Among various inflammatory mediators, CXC chemokines including IL-8 (CXCL8), MIP-2 (CXCL2), and KC (CXCL1) are the most critical for such recruitment. Neutrophils have been considered as effector cells that kill bacteria or destroy affected tissues mainly through the production of reactive oxygen species. Recent studies, however, revealed that neutrophils are involved in the production of chemokines in response to a variety of stimulants including LPS, TNF-alpha, and IFN-gamma, thereby contributing to immunomodulation. These functions are also regulated by selectins during infiltration into various sites. In this review, I summarize the current knowledge on this area and propose that neutrophils are a fascinating target for basic as well as clinical scientists.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2400-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The role of chemokines in neutrophil biology.
pubmed:affiliation
Division of Molecular Medicine, Dept. of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba, Japan. yoshiro@violet.biomol.sci.toho-u.ac.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't