Linked Life Data

17981659

Source:http://linkedlifedata.com/resource/pubmed/id/17981659

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-5
pubmed:abstractText
Precise removal of introns from metazoan precursor mRNAs is critical for gene expression. Nevertheless, alternative splicing provides a means for higher eukaryotes to increase genomic complexity and proteome diversity and to regulate certain cellular functions. The presence of rare U12-type pre-mRNA introns in eukaryotic genomes further complicates splicing events. In this review, we discuss the mechanism of U12-type intron splicing with emphasis on how the U12 spliceosome selects alternative splice sites in various U12-type intron-containing pre-mRNAs. Moreover, we propose possible roles for U12-type introns in a wide range of gene regulation through splicing regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1681-90
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Alternative splicing of U12-type introns.
pubmed:affiliation
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't