Linked Life Data

17981641

Source:http://linkedlifedata.com/resource/pubmed/id/17981641

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-5
pubmed:abstractText
Although originally described as a potent T cell growth factor in vitro, the main non redundant role of interleukin-2 (IL-2) in vivo is now known to be the maintenance of peripheral T cell tolerance. As well as promoting the proliferation and survival of recently activated effector T cells, IL-2 also plays a critical role in regulatory T cell (Treg) homeostasis and has been variously described as promoting the thymic development, peripheral homeostasis and suppressive function of Tregs. These observations, stemming largely from studies on various murine models of IL-2 and IL-2 receptor deficiency, have prompted a greater understanding of the pro-tolerogenic nature of IL-2 dependent signaling. Here we discuss current knowledge concerning the importance of IL-2 mediated signaling in Treg biology as well as its relevance to possible therapeutic applications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1440-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells.
pubmed:affiliation
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article, Review