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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-9
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pubmed:abstractText |
Matrix metalloproteinase-9 (MMP-9) has been implicated in the breakdown of the blood-brain barrier during cerebral ischemia. As a result, inhibition of MMP-9 may have utility as a therapeutic intervention in stroke. Towards this end, we have synthesized a series of 1-hydroxy-2-pyridinones that have excellent in vitro potency in inhibiting MMP-9 in addition to MMP-2. Representative compounds also demonstrate good efficacy in the mouse transient mid-cerebral artery occlusion (tMCAO) model of cerebral ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BurkeSharon LSL,
pubmed-author:ChakaravartyDevrajD,
pubmed-author:FanXiaodongX,
pubmed-author:HuangZhihongZ,
pubmed-author:JacksonPaul FPF,
pubmed-author:KarnachiPrabhaP,
pubmed-author:MaJianyaJ,
pubmed-author:RhodesKenneth JKJ,
pubmed-author:ScannevinRobert HRH,
pubmed-author:XiangBangpingB,
pubmed-author:ZhangYue-MeiYM
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
409-13
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pubmed:meshHeading |
pubmed-meshheading:17981034-Administration, Oral,
pubmed-meshheading:17981034-Animals,
pubmed-meshheading:17981034-Biological Availability,
pubmed-meshheading:17981034-Brain Ischemia,
pubmed-meshheading:17981034-Disease Models, Animal,
pubmed-meshheading:17981034-Inhibitory Concentration 50,
pubmed-meshheading:17981034-Male,
pubmed-meshheading:17981034-Matrix Metalloproteinase 2,
pubmed-meshheading:17981034-Matrix Metalloproteinase 9,
pubmed-meshheading:17981034-Mice,
pubmed-meshheading:17981034-Mice, Inbred C57BL,
pubmed-meshheading:17981034-Models, Molecular,
pubmed-meshheading:17981034-Protease Inhibitors,
pubmed-meshheading:17981034-Pyridones,
pubmed-meshheading:17981034-Structure-Activity Relationship,
pubmed-meshheading:17981034-Sulfonamides,
pubmed-meshheading:17981034-Zinc
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pubmed:year |
2008
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pubmed:articleTitle |
1-Hydroxy-2-pyridinone-based MMP inhibitors: synthesis and biological evaluation for the treatment of ischemic stroke.
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pubmed:affiliation |
East Coast Research and Early Development, Johnson & Johnson Pharmaceutical Research and Development, Welsh & McKean Roads, Spring House, PA 19477, USA. yzhang5@prdus.jnj.com
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pubmed:publicationType |
Journal Article
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