Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-29
pubmed:abstractText
Previous studies suggest that the anterior cingulate and other prefrontal brain regions might form a functionally-integrated error detection network in the human brain. This study examined whole brain functional connectivity to both correct and incorrect button presses using independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) data collected from 25 adolescent and 25 adult healthy participants (ages 11-37) performing a visual Go/No-Go task. Correct responses engaged a network comprising left lateral prefrontal cortex, left postcentral gyrus/inferior parietal lobule, striatum, and left cerebellum. In contrast, a similar network was uniquely engaged during errors, but this network was not integrated with activity in regions believed to be engaged for higher-order cognitive control over behavior. A medial/dorsolateral prefrontal-parietal neural network responded to all No-Go stimuli, but with significantly greater activity to errors. ICA analyses also identified a third error-related circuit comprised of anterior temporal lobe, limbic, and pregenual cingulate cortices, possibly representing an affective response to errors. There were developmental differences in error-processing activity within many of these neural circuits, typically reflecting greater hemodynamic activation in adults. These findings characterize the spatial structure of neural networks underlying error commission and identify neurobiological differences between adolescents and adults.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/1 R01 MH070539-01, http://linkedlifedata.com/resource/pubmed/grant/1 R01 MH071896-01, http://linkedlifedata.com/resource/pubmed/grant/K23, http://linkedlifedata.com/resource/pubmed/grant/P50-AA12870, http://linkedlifedata.com/resource/pubmed/grant/R01 AA015615, http://linkedlifedata.com/resource/pubmed/grant/R01 AA015615-01, http://linkedlifedata.com/resource/pubmed/grant/R01 AA015615-02, http://linkedlifedata.com/resource/pubmed/grant/R01 AA015615-03, http://linkedlifedata.com/resource/pubmed/grant/R01 AA015615-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DA020709, http://linkedlifedata.com/resource/pubmed/grant/R01 DA020709-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 DA020709-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DA020709-03, http://linkedlifedata.com/resource/pubmed/grant/R01 EB 000840, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000840-01, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000840-02, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000840-03, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000840-04, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000840-05, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000840-06, http://linkedlifedata.com/resource/pubmed/grant/R01 EB000840-07, http://linkedlifedata.com/resource/pubmed/grant/R01 EB005846, http://linkedlifedata.com/resource/pubmed/grant/R01 EB005846-01, http://linkedlifedata.com/resource/pubmed/grant/R01 EB005846-02, http://linkedlifedata.com/resource/pubmed/grant/R01 EB005846-03, http://linkedlifedata.com/resource/pubmed/grant/R01 EB005846-04, http://linkedlifedata.com/resource/pubmed/grant/R01 MH070539-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 MH070539-02, http://linkedlifedata.com/resource/pubmed/grant/R01 MH070539-03, http://linkedlifedata.com/resource/pubmed/grant/R01 MH070539-04, http://linkedlifedata.com/resource/pubmed/grant/R01 MH071896-01A2, http://linkedlifedata.com/resource/pubmed/grant/R01 MH071896-02, http://linkedlifedata.com/resource/pubmed/grant/R01 MH071896-03, http://linkedlifedata.com/resource/pubmed/grant/R01 MH071896-04
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
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