Linked Life Data

17978556

Source:http://linkedlifedata.com/resource/pubmed/id/17978556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-11-5
pubmed:abstractText
In pharmacotherapy, to alleviate pains of patients and to provide comforts to patients, pharmacists should improve their pharmaceutical skills of their clinical sense involving pharmaceutical investigational outcomes. Without pharmaceutical skills, pharmacists cannot apply the essence of drug therapies for patients in the most urgent 24 hours treatment. To cope with these drug therapies, we have developed search methods which easily identify the diachronic change of protein binding and the factors in serum (=a new pharmaceutical distribution diagnostic method). This method can speculate diachronic change factors in serum, by monitoring diachronically binding capacities of drug binding sites on human serum albumin (HSA) and alpha(1)-acid glycoprotein (AGP) molecules in patient sera (add each site probe to each patient serum, and measure the free level of each probe by using TDX/FLX analyzer and HPLC detector), and considering the binding capacities and values of HSA, AGP, free fatty acids, bilirubin (Bil) and blood urea nitrogen (BUN) associating with the amounts of uremic toxins laboratory tests. In addition, the diagnostic method could attempt effective administration by using the protein binding displacement of drugs that have a high protein binding capacity and small distribution volume, or high targeting (=the pharmaceutical skill of protein binding displacement). We have practiced pain control of patients with rheumatoid arthritis by the pharmaceutical skill. It is important for pharmacists to master the pharmaceutical skill in pharmacotherapy.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0031-6903
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1805-11
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
[Need for pharmaceutical skill in using displacement of protein binding].
pubmed:affiliation
Second Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Yoshino, Nobeoka City, Japan. noritotaka@phoenix.ac.jp
pubmed:publicationType
Journal Article, English Abstract, Review, Case Reports