Source:http://linkedlifedata.com/resource/pubmed/id/17977916
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-1-10
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| pubmed:abstractText |
The present study was designed to determine ANG peptide content [ANG I, ANG II, ANG-(1-7)], ACE2 mRNA, and the immunocytochemical distribution of ANG-(1-7) and ACE2 in the uteroembryonic unit during early and late gestation in Sprague-Dawley rats and in a rat model of pregnancy-induced hypertension, the reduced uterine perfusion pressure (RUPP) model. At early pregnancy ANG-(1-7) and ACE2 staining were localized in the primary and secondary decidual zone and luminal and glandular epithelial cells. During late gestation, ANG-(1-7) and ACE2 staining was visualized in the labyrinth placenta and amniotic and yolk sac epithelium. Uterine ANG II concentration at early pregnancy was significantly decreased by 21-55% in the implantation and interimplantation sites compared with virgin rats, whereas ANG-(1-7) levels were maintained at prepregnancy levels. At late gestation, uterine concentrations of ANG I and ANG II were significantly increased (30% and 25%, respectively). In RUPP animals, ANG-(1-7) concentration is significantly reduced in the uterus (181 +/- 16 vs. 372 +/- 74 fmol/g of tissue) and placenta (143 +/- 26 vs. 197 +/- 20 fmol/g of tissue). ACE2 mRNA increased in the uterus of early pregnant compared with virgin rats, yet within the implantation site it was downregulated. At late pregnancy, ACE2 mRNA is elevated by 58% in the uterus and decreased by 59% in RUPP animals. The regulation of ANG-(1-7) and ACE2 in early and late pregnancy supports the hypothesis that ANG-(1-7) and ACE2 may act as a local autocrine/paracrine regulator throughout pregnancy, participating in the early (angiogenesis, apoptosis, and growth) and late (uteroplacental blood flow) events of pregnancy.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin I,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/angiotensin I (1-7),
http://linkedlifedata.com/resource/pubmed/chemical/angiotensin converting enzyme 2
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0363-6119
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
294
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
R151-61
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| pubmed:dateRevised |
2008-10-31
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| pubmed:meshHeading |
pubmed-meshheading:17977916-Amnion,
pubmed-meshheading:17977916-Angiotensin I,
pubmed-meshheading:17977916-Angiotensin II,
pubmed-meshheading:17977916-Animals,
pubmed-meshheading:17977916-Decidua,
pubmed-meshheading:17977916-Disease Models, Animal,
pubmed-meshheading:17977916-Epithelial Cells,
pubmed-meshheading:17977916-Female,
pubmed-meshheading:17977916-Hypertension, Pregnancy-Induced,
pubmed-meshheading:17977916-Peptide Fragments,
pubmed-meshheading:17977916-Peptidyl-Dipeptidase A,
pubmed-meshheading:17977916-Placenta,
pubmed-meshheading:17977916-Pregnancy,
pubmed-meshheading:17977916-Pregnancy, Animal,
pubmed-meshheading:17977916-RNA, Messenger,
pubmed-meshheading:17977916-Rats,
pubmed-meshheading:17977916-Rats, Sprague-Dawley,
pubmed-meshheading:17977916-Uterus,
pubmed-meshheading:17977916-Yolk Sac
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| pubmed:year |
2008
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| pubmed:articleTitle |
ACE2 and ANG-(1-7) in the rat uterus during early and late gestation.
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| pubmed:affiliation |
Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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