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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
A variety of N-(2-amino-phenyl)-4-(heteroarylmethyl)-benzamides were designed and synthesized. These compounds were shown to inhibit recombinant human HDAC1 with IC(50) values in the sub-micromolar range. In human cancer cells growing in culture these compounds induced hyperacetylation of histones, induced the expression of the tumor suppressor protein p21(WAF1/Cip1), and inhibited cellular proliferation. Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BernsteinNaomyN,
pubmed-author:BestermanJeffrey MJM,
pubmed-author:BouchainGilianeG,
pubmed-author:DelormeDanielD,
pubmed-author:FournelMarielleM,
pubmed-author:FrechetteSylvieS,
pubmed-author:GaudetteFredericF,
pubmed-author:GillespieJeffJ,
pubmed-author:JinZhiyunZ,
pubmed-author:LeitSilvanaS,
pubmed-author:LiZuomeiZ,
pubmed-author:LuAihuaA,
pubmed-author:MacleodA RobertAR,
pubmed-author:MoradeiOscarO,
pubmed-author:PaquinIsabelleI,
pubmed-author:RaeppelStephaneS,
pubmed-author:RahilJubrailJ,
pubmed-author:RobertMarie-FranceMF,
pubmed-author:Trachy-BourgetMarie-ClaudeMC,
pubmed-author:VaisburgArkadiiA,
pubmed-author:WangJamesJ,
pubmed-author:WooSoon HyungSH,
pubmed-author:YanPu TheresaPT,
pubmed-author:YukJimmyJ,
pubmed-author:ZhouNancyN
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6729-33
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17977726-Amination,
pubmed-meshheading:17977726-Animals,
pubmed-meshheading:17977726-Anthranilic Acids,
pubmed-meshheading:17977726-Benzamides,
pubmed-meshheading:17977726-Binding Sites,
pubmed-meshheading:17977726-Cell Line,
pubmed-meshheading:17977726-Enzyme Inhibitors,
pubmed-meshheading:17977726-Histone Deacetylase Inhibitors,
pubmed-meshheading:17977726-Histone Deacetylases,
pubmed-meshheading:17977726-Humans,
pubmed-meshheading:17977726-Methylation,
pubmed-meshheading:17977726-Mice,
pubmed-meshheading:17977726-Models, Molecular,
pubmed-meshheading:17977726-Molecular Structure,
pubmed-meshheading:17977726-Niacin,
pubmed-meshheading:17977726-Structure-Activity Relationship,
pubmed-meshheading:17977726-Urea,
pubmed-meshheading:17977726-Vasodilation
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pubmed:year |
2007
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pubmed:articleTitle |
N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.
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pubmed:affiliation |
MethylGene Inc., Department of Chemistry, 7220 Frederick-Banting, Montréal, Que., Canada.
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pubmed:publicationType |
Journal Article
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