Linked Life Data

17977484

Source:http://linkedlifedata.com/resource/pubmed/id/17977484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Suppl 46
pubmed:dateCreated
2007-11-5
pubmed:abstractText
Co-stimulatory pathways are a prerequisite for the regulation of T-cell activation and tolerance. After the engagement of the T-cell receptor (TCR) to the major histocompatibility complex (MHC)/peptide complex, the co-stimulatory signals are critical to decide the outcome of the immune response. While positive co-stimulatory signals promote T-cell activation, negative signals delivered through inducible co-inhibitory receptors limit immune response, thereby regulating tolerance and autoimmunity. This review is intended not only to give an overview of the immunobiology of co-stimulatory pathways and their role in autoimmune diseases, but will also highlight the complexities and relevant issues one may have to think through to translate the target-ing of co-stimulatory pathways into successful therapeutic interventions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0392-856X
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S12-21
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:articleTitle
The evolution of the immunobiology of co-stimulatory pathways: clinical implications.
pubmed:affiliation
Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
pubmed:publicationType
Journal Article, Review