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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
Several P4 domain derivatives of the general d-phenylglycinamide-based scaffold (2) were synthesized and evaluated for their ability to bind to the serine protease factor Xa. Some of the more potent compounds were evaluated for their anticoagulant effects in vitro. A select subset containing various P1 indole constructs was further evaluated for their pharmacokinetic properties after oral administration to rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:ChastainMarcia KMK,
pubmed-author:ChouinardMichaelM,
pubmed-author:CraftTrelia JTJ,
pubmed-author:FosterRonald SRS,
pubmed-author:FranciskovichJeffry BJB,
pubmed-author:FroelichLarry LLL,
pubmed-author:Gifford-MooreDonetta SDS,
pubmed-author:JohnsonLea MLM,
pubmed-author:KlimkowskiValentine JVJ,
pubmed-author:LiebeschuetzJohn WJW,
pubmed-author:MastersJohn JJJ,
pubmed-author:MurrayChristopher WCW,
pubmed-author:SipesPhilip RPR,
pubmed-author:SmallwoodJeffrey KJK,
pubmed-author:SmithGerald FGF,
pubmed-author:SnyderDavid WDW,
pubmed-author:TownerRichard DRD,
pubmed-author:WeberWayne WWW,
pubmed-author:YoungStephen CSC
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6910-3
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pubmed:meshHeading |
pubmed-meshheading:17976987-Anticoagulants,
pubmed-meshheading:17976987-Antithrombin III,
pubmed-meshheading:17976987-Crystallography, X-Ray,
pubmed-meshheading:17976987-Factor Xa,
pubmed-meshheading:17976987-Glycine,
pubmed-meshheading:17976987-Humans,
pubmed-meshheading:17976987-Models, Molecular,
pubmed-meshheading:17976987-Molecular Structure,
pubmed-meshheading:17976987-Protein Binding,
pubmed-meshheading:17976987-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Investigation of the terminal P4 domain in a series of D-phenylglycinamide-based factor Xa inhibitors.
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pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
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pubmed:publicationType |
Journal Article
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