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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
This paper reports the synthesis and biological activity of a novel series of aryl-morpholine dopamine receptor agonists. Several compounds show high levels of functional selectivity for the D3 over the D2 dopamine receptor. Compound 26 has >1000-fold functional selectivity and has been successfully progressed in vivo using an intranasal delivery route.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AllertonCharlotte M NCM,
pubmed-author:BatchelorDavid V JDV,
pubmed-author:BaxterAndrew DAD,
pubmed-author:BlaggJulianJ,
pubmed-author:BurringDenise JDJ,
pubmed-author:CarrChristopher LCL,
pubmed-author:CookAndrew SAS,
pubmed-author:NicholsCarly LCL,
pubmed-author:PhippsJoanneJ,
pubmed-author:SandersonVivienne GVG,
pubmed-author:VerrierHughH,
pubmed-author:WongStephenS
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6691-6
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pubmed:meshHeading |
pubmed-meshheading:17976986-Administration, Intranasal,
pubmed-meshheading:17976986-Animals,
pubmed-meshheading:17976986-Crystallography, X-Ray,
pubmed-meshheading:17976986-Dogs,
pubmed-meshheading:17976986-Dopamine Agonists,
pubmed-meshheading:17976986-Drug Design,
pubmed-meshheading:17976986-Humans,
pubmed-meshheading:17976986-Models, Molecular,
pubmed-meshheading:17976986-Molecular Structure,
pubmed-meshheading:17976986-Rats,
pubmed-meshheading:17976986-Receptors, Dopamine D3,
pubmed-meshheading:17976986-Stereoisomerism,
pubmed-meshheading:17976986-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.
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pubmed:affiliation |
Pfizer Global Research & Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
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pubmed:publicationType |
Journal Article
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