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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-11-2
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pubmed:abstractText |
Soluble complement receptor-1 (sCR1), a potent complement inhibitor, confers neuroprotection in a murine stroke model. Additional neuroprotective benefit is achieved by sLe x-glycosylation of sCR1. In an effort to translate sCR1-sLe x to clinical trials, we evaluated this agent in a primate stroke model.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0047-2565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-80
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pubmed:meshHeading |
pubmed-meshheading:17976043-Animals,
pubmed-meshheading:17976043-Brain Ischemia,
pubmed-meshheading:17976043-Cerebral Infarction,
pubmed-meshheading:17976043-Complement Hemolytic Activity Assay,
pubmed-meshheading:17976043-Disease Models, Animal,
pubmed-meshheading:17976043-Drug Evaluation, Preclinical,
pubmed-meshheading:17976043-Male,
pubmed-meshheading:17976043-Neuroprotective Agents,
pubmed-meshheading:17976043-Papio anubis,
pubmed-meshheading:17976043-Random Allocation,
pubmed-meshheading:17976043-Receptors, Complement,
pubmed-meshheading:17976043-Reperfusion Injury,
pubmed-meshheading:17976043-Stroke,
pubmed-meshheading:17976043-Time Factors,
pubmed-meshheading:17976043-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Pre-clinical evaluation of an sLe x-glycosylated complement inhibitory protein in a non-human primate model of reperfused stroke.
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pubmed:affiliation |
Department of Neurological Surgery, Columbia University, New York, NY, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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