Linked Life Data

1797553

Source:http://linkedlifedata.com/resource/pubmed/id/1797553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-4-16
pubmed:abstractText
The present study was to investigate the role of '5-HT2-like' receptors in the circumventricular organs in the pressor response elicited by the central injection of serotonin (5-HT) to conscious rats. The increase in blood pressure induced by intracerebroventricular (i.c.v.) 5-HT (2.5 micrograms) was attenuated by intravenous pretreatment will, the peripheral 5-HT2 antagonist xylamidine (100 or 300 micrograms/kg). A combination of xylamidine with prazosin or a V1-vasopressin antagonist did not produce a further attenuation in the pressor response. Our data suggest that when administered i.c.v., 5-HT increases blood pressure by acting on 5-HT2-like receptors located in circumventricular organs as well as areas of the brain protected by the blood-brain barrier.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
203
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pharmacological evidence that circumventricular organs may participate in the pressor effect of central serotonin.
pubmed:affiliation
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66103.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't