|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5851
|
|
pubmed:dateCreated |
2007-11-2
|
|
pubmed:abstractText |
The limb blastemal cells of an adult salamander regenerate the structures distal to the level of amputation, and the surface protein Prod 1 is a critical determinant of their proximodistal identity. The anterior gradient protein family member nAG is a secreted ligand for Prod 1 and a growth factor for cultured newt blastemal cells. nAG is sequentially expressed after amputation in the regenerating nerve and the wound epidermis-the key tissues of the stem cell niche-and its expression in both locations is abrogated by denervation. The local expression of nAG after electroporation is sufficient to rescue a denervated blastema and regenerate the distal structures. Our analysis brings together the positional identity of the blastema and the classical nerve dependence of limb regeneration.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-10770844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-12408806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-12477722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-1255117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-12560810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-12592373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-12748649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-13787331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-14594207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-14829596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-14949331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-15136146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-15733667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-15935701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-16373567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-16522871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-1719886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-17631442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-17975053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-18873226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-3168786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-3291642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-3698099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-4328788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-6076915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-6474177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-6724131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-7024467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-7057925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-8805274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-8951064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-9082990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-9493827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-9533957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-9788443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17975060-9790916
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
2
|
|
pubmed:volume |
318
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
772-7
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17975060-Animals,
pubmed-meshheading:17975060-Antigens, CD59,
pubmed-meshheading:17975060-COS Cells,
pubmed-meshheading:17975060-Cells, Cultured,
pubmed-meshheading:17975060-Cercopithecus aethiops,
pubmed-meshheading:17975060-Denervation,
pubmed-meshheading:17975060-Extremities,
pubmed-meshheading:17975060-Glycosylphosphatidylinositols,
pubmed-meshheading:17975060-Growth Substances,
pubmed-meshheading:17975060-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:17975060-Ligands,
pubmed-meshheading:17975060-Mice,
pubmed-meshheading:17975060-Notophthalmus viridescens,
pubmed-meshheading:17975060-Peripheral Nerves,
pubmed-meshheading:17975060-Regeneration,
pubmed-meshheading:17975060-Stem Cells,
pubmed-meshheading:17975060-Two-Hybrid System Techniques
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate.
|
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
