pubmed-article:17973556 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17973556 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
pubmed-article:17973556 | lifeskim:mentions | umls-concept:C0949629 | lld:lifeskim |
pubmed-article:17973556 | lifeskim:mentions | umls-concept:C0449445 | lld:lifeskim |
pubmed-article:17973556 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:17973556 | pubmed:dateCreated | 2007-11-1 | lld:pubmed |
pubmed-article:17973556 | pubmed:abstractText | This work integrates two important cellular responses to low doses, detrimental bystander effects and apoptosis-mediated protective bystander effects, into a multistage model for chromosome aberrations and in vitro neoplastic transformation: the State-Vector Model. The new models were tested on representative data sets that show supralinear or U-shaped dose responses. The original model without the new low-dose features was also tested for consistency with LNT-shaped dose responses. Reductions of in vitro neoplastic transformation frequencies below the spontaneous level have been reported after exposure of cells to low doses of low-LET radiation. In the current study, this protective effect is explained with bystander-induced apoptosis. An important data set that shows a low-dose detrimental bystander effect for chromosome aberrations was successfully fitted by additional terms within the cell initiation stage. It was found that this approach is equivalent to bystander-induced clonal expansion of initiated cells. This study is an important step toward a comprehensive model that contains all essential biological mechanisms that can influence dose-response curves at low doses. | lld:pubmed |
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pubmed-article:17973556 | pubmed:language | eng | lld:pubmed |
pubmed-article:17973556 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17973556 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17973556 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17973556 | pubmed:month | Nov | lld:pubmed |
pubmed-article:17973556 | pubmed:issn | 0033-7587 | lld:pubmed |
pubmed-article:17973556 | pubmed:author | pubmed-author:HofmannWW | lld:pubmed |
pubmed-article:17973556 | pubmed:author | pubmed-author:RedpathJ LJL | lld:pubmed |
pubmed-article:17973556 | pubmed:author | pubmed-author:Crawford-Brow... | lld:pubmed |
pubmed-article:17973556 | pubmed:author | pubmed-author:Schöllnberger... | lld:pubmed |
pubmed-article:17973556 | pubmed:author | pubmed-author:MitchelR E... | lld:pubmed |
pubmed-article:17973556 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17973556 | pubmed:volume | 168 | lld:pubmed |
pubmed-article:17973556 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17973556 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17973556 | pubmed:pagination | 614-26 | lld:pubmed |
pubmed-article:17973556 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
pubmed-article:17973556 | pubmed:meshHeading | pubmed-meshheading:17973556... | lld:pubmed |
pubmed-article:17973556 | pubmed:meshHeading | pubmed-meshheading:17973556... | lld:pubmed |
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pubmed-article:17973556 | pubmed:meshHeading | pubmed-meshheading:17973556... | lld:pubmed |
pubmed-article:17973556 | pubmed:meshHeading | pubmed-meshheading:17973556... | lld:pubmed |
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pubmed-article:17973556 | pubmed:meshHeading | pubmed-meshheading:17973556... | lld:pubmed |
pubmed-article:17973556 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17973556 | pubmed:articleTitle | Detrimental and protective bystander effects: a model approach. | lld:pubmed |
pubmed-article:17973556 | pubmed:affiliation | Department of Materials Engineering and Physics and Biophysics, University of Salzburg, Salzburg, Austria. helmut.schoellnberger@sbg.ac.at | lld:pubmed |
pubmed-article:17973556 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17973556 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |