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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-11-1
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pubmed:abstractText |
This work integrates two important cellular responses to low doses, detrimental bystander effects and apoptosis-mediated protective bystander effects, into a multistage model for chromosome aberrations and in vitro neoplastic transformation: the State-Vector Model. The new models were tested on representative data sets that show supralinear or U-shaped dose responses. The original model without the new low-dose features was also tested for consistency with LNT-shaped dose responses. Reductions of in vitro neoplastic transformation frequencies below the spontaneous level have been reported after exposure of cells to low doses of low-LET radiation. In the current study, this protective effect is explained with bystander-induced apoptosis. An important data set that shows a low-dose detrimental bystander effect for chromosome aberrations was successfully fitted by additional terms within the cell initiation stage. It was found that this approach is equivalent to bystander-induced clonal expansion of initiated cells. This study is an important step toward a comprehensive model that contains all essential biological mechanisms that can influence dose-response curves at low doses.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0033-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
614-26
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:17973556-Bystander Effect,
pubmed-meshheading:17973556-Cell Survival,
pubmed-meshheading:17973556-Cell Transformation, Neoplastic,
pubmed-meshheading:17973556-Computer Simulation,
pubmed-meshheading:17973556-Cytoprotection,
pubmed-meshheading:17973556-Dose-Response Relationship, Radiation,
pubmed-meshheading:17973556-Models, Biological,
pubmed-meshheading:17973556-Radiation Dosage
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pubmed:year |
2007
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pubmed:articleTitle |
Detrimental and protective bystander effects: a model approach.
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pubmed:affiliation |
Department of Materials Engineering and Physics and Biophysics, University of Salzburg, Salzburg, Austria. helmut.schoellnberger@sbg.ac.at
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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