Linked Life Data

17973470

Source:http://linkedlifedata.com/resource/pubmed/id/17973470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2007-11-26
pubmed:abstractText
Conjugates of curcumin to two differently sized poly(ethylene glycol) molecules were synthesized in an attempt to overcome the low aqueous solubility of this natural product with cytotoxic activity against some human cancer cell lines. The soluble conjugates exhibited enhanced cytotoxicity as compared to that of the parent drug. Synthesis, analyses of the rate of drug release, and cytotoxicity studies are herein reported. The water-soluble conjugates may provide information useful for the development of injectable curcumin conjugates.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6284-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Design and development of water-soluble curcumin conjugates as potential anticancer agents.
pubmed:affiliation
Department of Radiation Oncology, University of Alabama at Birmingham, 1824 6th Avenue S., Birmingham, AL 35294-6832, USA. safavy@uab.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural