|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001038,
umls-concept:C0017337,
umls-concept:C0022209,
umls-concept:C0025663,
umls-concept:C0026882,
umls-concept:C0032659,
umls-concept:C0067787,
umls-concept:C0086418,
umls-concept:C0124604,
umls-concept:C0200932,
umls-concept:C0332307,
umls-concept:C0598322,
umls-concept:C0680730,
umls-concept:C1135166,
umls-concept:C1148554,
umls-concept:C1366556,
umls-concept:C1511790,
umls-concept:C1705513
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|
pubmed:issue |
2
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|
pubmed:dateCreated |
2007-11-1
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pubmed:abstractText |
Isoniazid (INH) is a drug widely used in the treatment of tuberculosis. INH is metabolized to acetylisoniazid by N-acetyltransferase (NAT) in the liver. The rate of INH acetylation is genetically determined. NAT isozymes are encoded at 2 loci; one encodes NAT1, formerly known as the monomorphic form of the enzyme, while the other encodes the polymorphic NAT2, which is responsible for individual differences in the ability to acetylate certain compounds. The objective of the present study was to apply the genotyping of the fast and slow acetylators for personalized therapeutic dose.
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pubmed:language |
pol
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0867-7077
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
75
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
134-9
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pubmed:dateRevised |
2010-9-8
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pubmed:meshHeading |
pubmed-meshheading:17973219-Acetylation,
pubmed-meshheading:17973219-Arylamine N-Acetyltransferase,
pubmed-meshheading:17973219-Genotype,
pubmed-meshheading:17973219-Humans,
pubmed-meshheading:17973219-Isoniazid,
pubmed-meshheading:17973219-Liver,
pubmed-meshheading:17973219-Mutation,
pubmed-meshheading:17973219-Polymerase Chain Reaction,
pubmed-meshheading:17973219-Polymorphism, Genetic,
pubmed-meshheading:17973219-Tuberculosis, Pulmonary
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
[Detection of mutation in NAT II gene as a method of determination of izoniazyd (INH) acetylation type in human population].
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|
pubmed:affiliation |
Zak?ad Mikrobiologii Instytutu Gruzlicy i Chorób P?uc w Warszawie.
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pubmed:publicationType |
Journal Article,
English Abstract
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