Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1992-4-15
pubmed:abstractText
The effect of stevioside, an inhibitor of long-chain fatty acid transport, on ketogenesis and on [14C]CO2 production from [1-14C]palmitate (100-300 microM) was investigated in the isolated and hemoglobin-free perfused rat liver. Stevioside (2.5 mM), a sweet glycoside found in Stevia rebaudiana leaves, inhibited both parameters, but had a lower effect on [14C]CO2 production. At 300 microM palmitate and 150 microM albumin, for example, ketogenesis was inhibited by 66.3%, whereas no significant inhibition of [14C]CO2 was demonstrable. These results were interpreted to reflect 1) different degrees of saturation of the citric acid cycle and the ketogenic pathway and 2) changes in the redox state of the mitochondrial NAD(+)-NADH couple which may also occur upon stevioside infusion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
767-71
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Sensitivity of ketogenesis and citric acid cycle to stevioside inhibition of palmitate transport across the cell membrane.
pubmed:affiliation
Departamento de Bioquímica, Universidade de Maringá, Brasil.
pubmed:publicationType
Journal Article