Linked Life Data

17971997

Source:http://linkedlifedata.com/resource/pubmed/id/17971997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2007-10-31
pubmed:abstractText
Formation of RNA/dendrimer complexes between various RNA molecules and PAMAM dendrimers was studied using atomic force microscopy. Our results demonstrate that effective construction of stable nanoscale and uniform RNA/dendrimer complexes depends critically on the size of the RNA molecule, the dendrimer generation and the charge ratio between the dendrimer and the RNA. Larger RNA molecules, higher generations of dendrimers and larger dendrimer-to-RNA charge ratios lead to the formation of stable, uniform nanoscale RNA/dendrimer complexes. These findings provide new insights in developing dendrimer systems for RNA delivery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1477-0520
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3674-81
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Importance of size-to-charge ratio in construction of stable and uniform nanoscale RNA/dendrimer complexes.
pubmed:affiliation
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P.R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't