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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-7-14
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pubmed:abstractText |
There is an enrichment of immune response genes that are subject to copy number variations (CNVs). However, there is limited understanding of their impact on susceptibility to human diseases. CC chemokine ligand 3 like-1 (CCL3L1) is a potent ligand for the HIV coreceptor, CC chemokine receptor 5 (CCR5), and we have demonstrated previously an association between CCL3L1-gene containing segmental duplications and polymorphisms in CCR5 and HIV/AIDS susceptibility. Here, we determined the association between these genetic variations and risk of developing systemic lupus erythaematosus (SLE), differential recruitment of CD3+ and CD68+ leukocytes to the kidney, clinical severity of SLE reflected by autoantibody titres and the risk of renal complications in SLE.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1468-2060
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1076-83
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pubmed:meshHeading |
pubmed-meshheading:17971457-Adult,
pubmed-meshheading:17971457-Antigens, CD,
pubmed-meshheading:17971457-Antigens, CD3,
pubmed-meshheading:17971457-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:17971457-Autoantibodies,
pubmed-meshheading:17971457-Case-Control Studies,
pubmed-meshheading:17971457-Chemokine CCL3,
pubmed-meshheading:17971457-Chemotaxis, Leukocyte,
pubmed-meshheading:17971457-Female,
pubmed-meshheading:17971457-Gene Dosage,
pubmed-meshheading:17971457-Genetic Predisposition to Disease,
pubmed-meshheading:17971457-Genotype,
pubmed-meshheading:17971457-Humans,
pubmed-meshheading:17971457-Kidney,
pubmed-meshheading:17971457-Leukocytes,
pubmed-meshheading:17971457-Logistic Models,
pubmed-meshheading:17971457-Lupus Erythematosus, Systemic,
pubmed-meshheading:17971457-Lupus Nephritis,
pubmed-meshheading:17971457-Male,
pubmed-meshheading:17971457-Middle Aged,
pubmed-meshheading:17971457-Polymorphism, Genetic,
pubmed-meshheading:17971457-Prospective Studies,
pubmed-meshheading:17971457-Receptors, CCR5,
pubmed-meshheading:17971457-Risk
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pubmed:year |
2008
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pubmed:articleTitle |
CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus.
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pubmed:affiliation |
The Veterans Administration Center for AIDS and HIV-1 Infection, South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center at San Antonio, Texas 78229-7870, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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