Source:http://linkedlifedata.com/resource/pubmed/id/17971453
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-12-31
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| pubmed:abstractText |
PNRC2 was identified in our laboratory as a general cofactor for nuclear receptors. To better characterize the physiological function of PNRC2, we used gene-targeting technology to generate PNRC2-null mice (PNRC2(-/-) mice). These PNRC2(-/-) mice are viable and fertile. PNRC2-null mice, especially male mice, are lean and are resistant to high fat diet-induced obesity but without the induction of insulin resistance. Male mice devoid of PNRC2 protein have a higher metabolic rate than wild-type mice. They consume more oxygen and produce more heat. Consistent with reduced adipose mass, the levels of leptin are lower in PNRC2(-/-) mice. This study provides evidence that PNRC2 plays one or more important roles in controlling the energy balance between energy storage and energy expenditure. PNRC2 may be a new target in the treatment of obesity and related metabolic diseases.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
0021-9258
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
4
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| pubmed:volume |
283
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
541-53
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| pubmed:meshHeading |
pubmed-meshheading:17971453-Adiposity,
pubmed-meshheading:17971453-Animals,
pubmed-meshheading:17971453-Blotting, Northern,
pubmed-meshheading:17971453-Blotting, Southern,
pubmed-meshheading:17971453-Body Mass Index,
pubmed-meshheading:17971453-Body Temperature,
pubmed-meshheading:17971453-Body Weight,
pubmed-meshheading:17971453-Calorimetry, Indirect,
pubmed-meshheading:17971453-Dietary Fats,
pubmed-meshheading:17971453-Eating,
pubmed-meshheading:17971453-Energy Metabolism,
pubmed-meshheading:17971453-Female,
pubmed-meshheading:17971453-Genotype,
pubmed-meshheading:17971453-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17971453-Male,
pubmed-meshheading:17971453-Mice,
pubmed-meshheading:17971453-Mice, Inbred C57BL,
pubmed-meshheading:17971453-Mice, Inbred Strains,
pubmed-meshheading:17971453-Mice, Knockout,
pubmed-meshheading:17971453-Obesity,
pubmed-meshheading:17971453-Phenotype,
pubmed-meshheading:17971453-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17971453-Trans-Activators
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| pubmed:year |
2008
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| pubmed:articleTitle |
Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity.
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| pubmed:affiliation |
Department of Surgical Research, Transgenic Mouse Facility, and Animal Resources Center, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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