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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-27
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pubmed:abstractText |
The study of FOP, a disabling genetic disorder of progressive heterotopic ossification, is hampered by the lack of readily available connective tissue progenitor cells. We isolated such cells from discarded primary teeth of patients with FOP and controls and discovered dysregulation of BMP signaling and rapid osteoblast differentiation in FOP cells compared with control cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-11087820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-12672843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-12700180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-12716973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-12717440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-12809600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-12930627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-12968668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-15459107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-15516492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-15845886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-15940369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-15964849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-16007337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-16222704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-16642017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-16753021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-16923969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-17051438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-17111383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-17272450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-17289590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-17572636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-2878930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-4564052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17967130-8678932
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ACVR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/BMP4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 4,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Smad Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1523-4681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-13
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17967130-Activin Receptors, Type I,
pubmed-meshheading:17967130-Bone Morphogenetic Protein 4,
pubmed-meshheading:17967130-Bone Morphogenetic Protein Receptors, Type I,
pubmed-meshheading:17967130-Bone Morphogenetic Proteins,
pubmed-meshheading:17967130-Cell Differentiation,
pubmed-meshheading:17967130-Cells, Cultured,
pubmed-meshheading:17967130-Gene Expression Regulation,
pubmed-meshheading:17967130-Humans,
pubmed-meshheading:17967130-MAP Kinase Signaling System,
pubmed-meshheading:17967130-Myositis Ossificans,
pubmed-meshheading:17967130-Osteogenesis,
pubmed-meshheading:17967130-Smad Proteins,
pubmed-meshheading:17967130-Stem Cells,
pubmed-meshheading:17967130-Tooth,
pubmed-meshheading:17967130-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2008
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pubmed:articleTitle |
Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP).
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pubmed:affiliation |
The Center for Research in FOP and Related Disorders, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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