Linked Life Data

17965450

Source:http://linkedlifedata.com/resource/pubmed/id/17965450

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-11-20
pubmed:abstractText
Metazoan species, from sponges to insects and mammals, possess successful defence systems against their pathogens and parasites. The evolutionary origins of these diverse systems are beginning to be more comprehensively investigated and mapped out. We have collected 1811 metazoan immunity genes from literature and gene ontology annotations. Tentative orthologs of these genes were identified using reciprocal protein-protein Blast searches against proteins from the GenBank and RefSeq databases. We have defined different levels or classes of ortholog group according to the order of reciprocal ortholog pairs among the seed immunity genes. The genes were clustered into these different ortholog groups. Initial phylogenetic analysis of these ortholog groups suggests that by this approach, we can collect a spectrum of immunity genes representing well the taxa in which they appear. All the immunity genes and their evidence of immune function, orthologs and ortholog groups have been combined into an open access database -- ImmunomeBase, which is publicly available from (http://bioinf.uta.fi/ImmunomeBase).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0953-8178
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1361-70
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Immunity genes and their orthologs: a multi-species database.
pubmed:affiliation
Bioinformatics Research Group, Institute of Medical Technology, FI-33014, University of Tampere, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't