Linked Life Data

17965255

Source:http://linkedlifedata.com/resource/pubmed/id/17965255

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pubmed-article:17965255pubmed:abstractTextCarnitine and acetylcarnitine are important for the acquisition of motility and maturation of spermatozoa in the epididymis. In this study, we examined the involvement of carnitine/organic cation transporter (OCTN) in carnitine and acetylcarnitine transport in epididymal spermatozoa of mice. Uptake of both compounds by epididymal spermatozoa was time-dependent and partially Na(+)-dependent. Kinetic analyses revealed the presence of a high-affinity transport system in the spermatozoa, with K(m) values of 23.6 and 6.57 muM for carnitine and acetylcarnitine respectively in the presence of Na(+). Expression of OCTN2 and OCTN3 in epididymal spermatozoa was confirmed by immunofluorescence analysis. The involvement of these two transporters in carnitine and acetylcarnitine transport was supported by a selective inhibition study. We conclude that both Na(+)-dependent and -independent carnitine transporters, OCTN2 and OCTN3, mediate the supply of carnitine and acetylcarnitine to epididymal spermatozoa in mice.lld:pubmed
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pubmed-article:17965255pubmed:dateRevised2008-7-9lld:pubmed
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pubmed-article:17965255pubmed:articleTitleTransport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.lld:pubmed
pubmed-article:17965255pubmed:affiliationDivision of Pharmaceutical Sciences, Department of Molecular Biopharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.lld:pubmed
pubmed-article:17965255pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17965255pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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