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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
Isoprenylcysteine methyltransferase (Icmt) catalyzes the carboxyl methylation of oncogenic proteins in the final step of a series of post-translational modifications. The inhibition of Icmt provides an attractive and novel anticancer target. A natural product high-throughput screening campaign was conducted to discover inhibitors of Icmt. The Australian marine sponge, Pseudoceratina sp., yielded spermatinamine, a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy. Spermatinamine is the first natural product inhibitor of Icmt.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AddepalliRamaR,
pubmed-author:AveryVicky MVM,
pubmed-author:BoyleAnthonyA,
pubmed-author:BuchananMalcolm SMS,
pubmed-author:CarrollAnthony RAR,
pubmed-author:ChenHuaweiH,
pubmed-author:FechnerGregory AGA,
pubmed-author:HooperJohn N AJN,
pubmed-author:QuinnRonald JRJ,
pubmed-author:SimpsonMoana MMM,
pubmed-author:SuNancyN
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6860-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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pubmed:year |
2007
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pubmed:articleTitle |
Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target.
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pubmed:affiliation |
Eskitis Institute, Griffith University, Brisbane, Qld 4111, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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