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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
Amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid were synthesized and evaluated for their anti-inflammatory and analgesic activity. Few selected compounds were also screened for their antipyretic, anti-arthritic, and ulcerogenic potential. Most of the compounds exhibited good activity profile and were free of gastrointestinal toxicity of common NSAIDs. However these compounds failed to decrease secondary lesions of adjuvant induced arthritis and also did not inhibit TNF-alpha in lipopolysaccharide induced pyresis.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6790-6
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pubmed:meshHeading |
pubmed-meshheading:17964781-Acetic Acids,
pubmed-meshheading:17964781-Amides,
pubmed-meshheading:17964781-Analgesics,
pubmed-meshheading:17964781-Animals,
pubmed-meshheading:17964781-Anti-Inflammatory Agents,
pubmed-meshheading:17964781-Arthritis,
pubmed-meshheading:17964781-Carrageenan,
pubmed-meshheading:17964781-Cytochrome P-450 Enzyme System,
pubmed-meshheading:17964781-Edema,
pubmed-meshheading:17964781-Enzyme Inhibitors,
pubmed-meshheading:17964781-Indenes,
pubmed-meshheading:17964781-Male,
pubmed-meshheading:17964781-Mice,
pubmed-meshheading:17964781-Molecular Structure,
pubmed-meshheading:17964781-Rats,
pubmed-meshheading:17964781-Ulcer
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pubmed:year |
2007
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pubmed:articleTitle |
Aromatic amide derivatives of 5,6-dimethoxy-2,3-dihydro-1H-inden(-1-yl)acetic acid as anti-inflammatory agents free of ulcerogenic liability.
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pubmed:affiliation |
Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Pilani 333031, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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