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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-12-14
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pubmed:abstractText |
A cohort of 10 Hashimoto's encephalopathy (HE) patients, 33 patients with unrelated neurological symptoms, 12 Hashimoto's thyroiditis patients and 4 healthy adult donors was studied to explore the neurological targets of anti-thyroperoxidase (TPO) autoantibodies (aAb) in HE. High levels of anti-TPO aAb were only detected in HE group's cerebrospinal fluids. In immunofluorescence assays on monkey brain cerebellum sections, both HE patients' sera and anti-TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein. Normal human astrocytes from primary cultures also reacted with anti-TPO mAb. Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:AlloucheStéphaneS,
pubmed-author:BalletJean JacquesJJ,
pubmed-author:BlanchinStéphanieS,
pubmed-author:CarayonPierreP,
pubmed-author:CoffinChristineC,
pubmed-author:CombyElisabethE,
pubmed-author:HoltDD,
pubmed-author:OllivierYannY,
pubmed-author:PortierEstelleE,
pubmed-author:PotierFrancetteF,
pubmed-author:ReznikYvesY,
pubmed-author:ViaderFaustoF
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pubmed:issnType |
Print
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-20
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pubmed:meshHeading |
pubmed-meshheading:17963848-Adult,
pubmed-meshheading:17963848-Aged,
pubmed-meshheading:17963848-Aged, 80 and over,
pubmed-meshheading:17963848-Analysis of Variance,
pubmed-meshheading:17963848-Astrocytes,
pubmed-meshheading:17963848-Autoantibodies,
pubmed-meshheading:17963848-Cells, Cultured,
pubmed-meshheading:17963848-Cerebellum,
pubmed-meshheading:17963848-Female,
pubmed-meshheading:17963848-Fetus,
pubmed-meshheading:17963848-Glial Fibrillary Acidic Protein,
pubmed-meshheading:17963848-Hashimoto Disease,
pubmed-meshheading:17963848-Humans,
pubmed-meshheading:17963848-Iodide Peroxidase,
pubmed-meshheading:17963848-Male,
pubmed-meshheading:17963848-Middle Aged,
pubmed-meshheading:17963848-Radioimmunoassay,
pubmed-meshheading:17963848-Thyroglobulin,
pubmed-meshheading:17963848-Thyroid Gland,
pubmed-meshheading:17963848-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes.
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pubmed:affiliation |
Laboratoire d'Immunologie et d'Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France. blanchin-s@chu-caen.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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