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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-10-26
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pubmed:abstractText |
Ethnic variation has been reported in age-related macular degeneration (AMD)-associated Y402H polymorphism in complement factor H (CFH). This variation is evident in the Japanese population. Recently a strong association between a novel single-nucleotide polymorphism (SNP; rs1410996) in the CFH gene and AMD has been identified in Caucasian patients. The present study was undertaken to investigate whether four coding and noncoding variants of the CFH gene, including rs1410996, are associated with AMD in native, unrelated Japanese patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5315-9
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pubmed:meshHeading |
pubmed-meshheading:17962488-Aged,
pubmed-meshheading:17962488-Aged, 80 and over,
pubmed-meshheading:17962488-Case-Control Studies,
pubmed-meshheading:17962488-Complement Factor H,
pubmed-meshheading:17962488-Female,
pubmed-meshheading:17962488-Gene Frequency,
pubmed-meshheading:17962488-Genotype,
pubmed-meshheading:17962488-Humans,
pubmed-meshheading:17962488-Introns,
pubmed-meshheading:17962488-Japan,
pubmed-meshheading:17962488-Macular Degeneration,
pubmed-meshheading:17962488-Male,
pubmed-meshheading:17962488-Middle Aged,
pubmed-meshheading:17962488-Open Reading Frames,
pubmed-meshheading:17962488-Polymorphism, Single Nucleotide,
pubmed-meshheading:17962488-RNA, Untranslated,
pubmed-meshheading:17962488-Risk Factors,
pubmed-meshheading:17962488-Smoking
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pubmed:year |
2007
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pubmed:articleTitle |
Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population.
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pubmed:affiliation |
Department of Ophthalmology, Saitama Medical School, Moroyama, Iruma, Saitama, Japan. keisuke@saitama-med.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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