Source:http://linkedlifedata.com/resource/pubmed/id/17962439
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2007-10-26
|
| pubmed:abstractText |
Concurrent loss of chromosome arm 1p, region 36, and chromosome 3 leads to decreased disease-free survival in patients with uveal melanoma. A candidate tumor-suppressor gene APITD1 is located on the critical region on chromosome arm 1p, and it was therefore hypothesized that lower expression levels of this gene could lead to decreased survival in patients, with concurrent loss of a region on chromosome arm 1p and chromosome 3. Using neuroblastoma cells, which, like uveal melanoma, originate from neural crest cells, a former study showed that APITD1 has cell growth and/or cell death properties. In this study, APITD1 expression was analyzed to determine whether it corresponds with the DNA copy number and is related to survival in uveal melanoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0146-0404
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
48
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4919-23
|
| pubmed:meshHeading |
pubmed-meshheading:17962439-Apoptosis,
pubmed-meshheading:17962439-Apoptosis Regulatory Proteins,
pubmed-meshheading:17962439-Chromosomes, Human, Pair 1,
pubmed-meshheading:17962439-Chromosomes, Human, Pair 3,
pubmed-meshheading:17962439-Gene Dosage,
pubmed-meshheading:17962439-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17962439-Humans,
pubmed-meshheading:17962439-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17962439-Melanoma,
pubmed-meshheading:17962439-Prognosis,
pubmed-meshheading:17962439-RNA, Messenger,
pubmed-meshheading:17962439-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17962439-Survival Rate,
pubmed-meshheading:17962439-Tumor Cells, Cultured,
pubmed-meshheading:17962439-Tumor Suppressor Proteins,
pubmed-meshheading:17962439-Uveal Neoplasms
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Expression of APITD1 is not related to copy number changes of chromosomal region 1p36 or the prognosis of uveal melanoma.
|
| pubmed:affiliation |
Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|