Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-10-26
pubmed:abstractText
Allogeneic stem cell transplantation (SCT) is the treatment of choice for the majority of young patients with myelodysplasia (MDS) who have a histocompatible donor (sibling or unrelated donor). For some patients lacking a human leukocyte antigen (HLA)-compatible donor, chemotherapy followed by autologous SCT may be a reasonable alternative, especially for patients with therapy-related MDS/acute myeloid leukemia (AML). A substantial number of candidates may not be eligible for autologous SCT due to failure to induce remission or failure to collect sufficient numbers of stem cells. Careful clinical evaluation of the prognostic factors, such as age, cytogenetic characteristics, chances of achieving complete remission (CR), and availability of a matched unrelated donor, may guide the treating physician in advising the patient about the available treatment options. Mobilized peripheral blood stem cells are the preferred stem cell source for young patients, especially in view of the more rapid hematopoietic recovery after transplantation with mobilized stem cells, but bone marrow stem cells also may be considered for patients older than 50 years. Further development of precise prognostic classification systems, including an accurate evaluation of cytogenetic/molecular response to chemotherapy, is needed to develop a risk-adapted strategy for individual patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0037-1963
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
274-7
pubmed:meshHeading
pubmed-meshheading:17961727-Adult, pubmed-meshheading:17961727-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:17961727-Bone Marrow Transplantation, pubmed-meshheading:17961727-Combined Modality Therapy, pubmed-meshheading:17961727-Disease-Free Survival, pubmed-meshheading:17961727-Evidence-Based Medicine, pubmed-meshheading:17961727-Hematopoietic Stem Cell Mobilization, pubmed-meshheading:17961727-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:17961727-Humans, pubmed-meshheading:17961727-Leukemia, Myeloid, Acute, pubmed-meshheading:17961727-Middle Aged, pubmed-meshheading:17961727-Myelodysplastic Syndromes, pubmed-meshheading:17961727-Peripheral Blood Stem Cell Transplantation, pubmed-meshheading:17961727-Remission Induction, pubmed-meshheading:17961727-Risk Assessment, pubmed-meshheading:17961727-Transplantation, Autologous, pubmed-meshheading:17961727-Transplantation, Homologous
pubmed:year
2007
pubmed:articleTitle
Autologous stem cell transplantation in myelodysplastic syndromes.
pubmed:affiliation
Department of Hematology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands, and Bone Marrow Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany. L.Brinkman@hemat.umcn.nl
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Evaluation Studies