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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-1-9
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pubmed:abstractText |
The cell cycles of the Xenopus laevis embryo undergo extensive remodeling beginning at the midblastula transition (MBT) of early development. Cell divisions 2-12 consist of rapid cleavages without gap phases or cell cycle checkpoints. Some remodeling events depend upon a critical nucleo-cytoplasmic ratio, whereas others rely on a maternal timer controlled by cyclin E/Cdk2 activity. One key event that occurs at the MBT is the degradation of maternal Wee1, a negative regulator of cyclin-dependent kinase (Cdk) activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-10433828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-10982403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-11030344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-11134069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-11251070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-11257126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-11585773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-12110582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-12217326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-12591601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-12914904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-1372994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-14712091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-14742443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-15115752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-15937936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-15996662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-1825699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-1825803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-1913817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-2005892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-2517560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-3032459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-6183003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7479751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7569953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7642695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7743995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7749193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7850420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7896832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-7989910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-8606001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-8700885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-9243501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-9268577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-9299125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-9486540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961226-9486797
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cdc25A protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk2 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin E,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Wee1b protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/cdc25 Phosphatases
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-213X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17961226-Animals,
pubmed-meshheading:17961226-Apoptosis,
pubmed-meshheading:17961226-Blastula,
pubmed-meshheading:17961226-Blotting, Western,
pubmed-meshheading:17961226-Cell Cycle Proteins,
pubmed-meshheading:17961226-Cyclin E,
pubmed-meshheading:17961226-Cyclin-Dependent Kinase 2,
pubmed-meshheading:17961226-Embryo, Nonmammalian,
pubmed-meshheading:17961226-Gene Expression Regulation, Developmental,
pubmed-meshheading:17961226-Protein-Tyrosine Kinases,
pubmed-meshheading:17961226-RNA, Messenger,
pubmed-meshheading:17961226-Xenopus Proteins,
pubmed-meshheading:17961226-Xenopus laevis,
pubmed-meshheading:17961226-cdc25 Phosphatases
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pubmed:year |
2007
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pubmed:articleTitle |
Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis.
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pubmed:affiliation |
Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. bwroble@vt.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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