Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-6
pubmed:abstractText
There is currently great interest in the idea of using helminth-derived molecules for therapeutic purposes and indeed we have shown that ES-62, a filarial nematode-derived phosphorylcholine-containing glycoprotein, significantly reduces the severity of arthritis in a murine model. Clearly, knowledge of mechanism of action is important when considering molecules for use in treating disease and although much is known regarding how ES-62 interacts with the immune system, gaps in our understanding remain. A feature of filarial nematode infection is a defective, T helper 2 (Th2)-polarized antigen-specific T-cell response and in relation to this we have recently shown that ES-62 inhibits clonal expansion and modulates effector function towards a Th2 phenotype, of antigen-specific T cells in vivo. ES-62 is also known to directly modulate B-cell behaviour and hence to determine whether it was mediating these effects on T cells by disrupting B-T-cell co-operation, we have investigated antigen-specific responses using an adoptive transfer system in which traceable numbers of tg ovalbumin (OVA)-specific T cells and hen egg lysozyme (HEL)-specific B cells respond to a chemically coupled form of OVA-HEL that contains linked epitopes that promote cognate T- and B-cell interactions. Surprisingly, these studies indicate that activated B cells restore T-cell expansion and prevent Th2-like polarization. However, ES-62-treated double cell transfer mice demonstrate a more generalized immunosuppression with reduced levels of Th1 and -2 type cytokines and antibody subclasses. Collectively, these results suggest that whilst ES-62 can target B-T-cell co-operation, this does not promote polarizing of T-cell responses towards a Th2-type phenotype.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10077632, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10229801, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10583862, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10617422, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10837075, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10843701, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10948186, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-10975827, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-11067910, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-11138628, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-11369785, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-11389964, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-11441102, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-11591802, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-11970973, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-12570785, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-12757619, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-12846803, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-12888794, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-12902519, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15009423, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15102768, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15128811, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15180890, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15234531, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15265892, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15463386, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-15554927, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-16011524, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-16237074, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-1717561, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-1747951, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-1846244, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-2125367, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-2437195, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-3107127, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-3115793, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-332621, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-6444695, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-7532460, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-7534202, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-7621080, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-7882172, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-8107800, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-8409441, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-8761566, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9176700, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9182685, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9317124, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9510168, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9550411, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9651253, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9806045, http://linkedlifedata.com/resource/pubmed/commentcorrection/17961164-9988312
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1365-2567
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
411-25
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...