Linked Life Data

17957187

Source:http://linkedlifedata.com/resource/pubmed/id/17957187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-18
pubmed:abstractText
Inheritance plays a significant role in defining drug response and toxicity. Advances in molecular pharmacology and modern genomics emphasize genetic variation in dictating inter-individual pharmacokinetics and pharmacodynamics. A case in point is the homeostatic ATP-sensitive potassium (K(ATP)) channel, an established drug target that adjusts membrane excitability to match cellular energetic demand. There is an increased recognition that genetic variability of the K(ATP) channel impacts therapeutic decision-making in human disease.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters, http://linkedlifedata.com/resource/pubmed/chemical/Anti-Arrhythmia Agents, http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Insulin, http://linkedlifedata.com/resource/pubmed/chemical/KATP Channels, http://linkedlifedata.com/resource/pubmed/chemical/Kir6.2 channel, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly..., http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug, http://linkedlifedata.com/resource/pubmed/chemical/sulfonylurea receptor
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1532-6535
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
354-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:17957187-ATP-Binding Cassette Transporters, pubmed-meshheading:17957187-Animals, pubmed-meshheading:17957187-Anti-Arrhythmia Agents, pubmed-meshheading:17957187-Arrhythmias, Cardiac, pubmed-meshheading:17957187-Diabetes Mellitus, pubmed-meshheading:17957187-Drug Design, pubmed-meshheading:17957187-Humans, pubmed-meshheading:17957187-Hypoglycemic Agents, pubmed-meshheading:17957187-Infant, Newborn, pubmed-meshheading:17957187-Infant, Newborn, Diseases, pubmed-meshheading:17957187-Insulin, pubmed-meshheading:17957187-Insulin-Secreting Cells, pubmed-meshheading:17957187-KATP Channels, pubmed-meshheading:17957187-Patient Selection, pubmed-meshheading:17957187-Persistent Hyperinsulinemia Hypoglycemia of Infancy, pubmed-meshheading:17957187-Pharmacogenetics, pubmed-meshheading:17957187-Polymorphism, Genetic, pubmed-meshheading:17957187-Potassium Channel Blockers, pubmed-meshheading:17957187-Potassium Channels, pubmed-meshheading:17957187-Potassium Channels, Inwardly Rectifying, pubmed-meshheading:17957187-Receptors, Drug
pubmed:year
2008
pubmed:articleTitle
K(ATP) channel pharmacogenomics: from bench to bedside.
pubmed:affiliation
Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural