| pubmed-article:17956668 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C1704939 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:17956668 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:17956668 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17956668 | pubmed:dateCreated | 2007-10-24 | lld:pubmed |
| pubmed-article:17956668 | pubmed:abstractText | This study was purposed to investigate whether the mdr1 participates in antiapoptotic mechanisms of hematologic malignant cells regulated by NF-kappaB and to explore the reversal effect of inhibiting NF-kappaB on drug-resistance of hematologic malignant cells so as to search a novel way for treatment of refractory leukemia. NF-kappaB activity and P-gp expression in K562/A02 cells cultured with PDTC in different concentration or different time were detected by immunohistochemistry and computerized picture analysis. The mdr1 was detected by reverse transcription-polymerase chain reaction, and the relationship among NF-kappaB, P-gp and mdr1 was analyzed. The results showed that in K562/A02 cells the expression of P-gp and mdr1 were positively correlated with NF-kappaB/p65, which showed the concentration and time dependent manner. It is concluded the mechanism of NF-kappaB regulating anti-apoptosis in K562/A02 cells has the correlation with the expression of mdr1 and P-gp. The expression of mdr 1 mRNA and P-gp can be reduced through inhibiting NF-kappaB in K562/A02 cells, so that the sensitivity of chemical therapy can be enhanced on hematologic malignant cells. | lld:pubmed |
| pubmed-article:17956668 | pubmed:language | chi | lld:pubmed |
| pubmed-article:17956668 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17956668 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17956668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17956668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17956668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17956668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17956668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17956668 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17956668 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17956668 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17956668 | pubmed:issn | 1009-2137 | lld:pubmed |
| pubmed-article:17956668 | pubmed:author | pubmed-author:SzeS HSH | lld:pubmed |
| pubmed-article:17956668 | pubmed:author | pubmed-author:WangYiY | lld:pubmed |
| pubmed-article:17956668 | pubmed:author | pubmed-author:YuMinM | lld:pubmed |
| pubmed-article:17956668 | pubmed:author | pubmed-author:WangHuiH | lld:pubmed |
| pubmed-article:17956668 | pubmed:author | pubmed-author:ZhangHai-TaoH... | lld:pubmed |
| pubmed-article:17956668 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17956668 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17956668 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17956668 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17956668 | pubmed:pagination | 950-4 | lld:pubmed |
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| pubmed-article:17956668 | pubmed:meshHeading | pubmed-meshheading:17956668... | lld:pubmed |
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| pubmed-article:17956668 | pubmed:meshHeading | pubmed-meshheading:17956668... | lld:pubmed |
| pubmed-article:17956668 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17956668 | pubmed:articleTitle | [NF-kappaB regulating expression of mdr1 gene and P-gp to reverse drug-resistance in leukemic cells]. | lld:pubmed |
| pubmed-article:17956668 | pubmed:affiliation | Department of Hematology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China. | lld:pubmed |
| pubmed-article:17956668 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17956668 | pubmed:publicationType | English Abstract | lld:pubmed |
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