Source:http://linkedlifedata.com/resource/pubmed/id/17956354
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
Pt 5
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pubmed:dateCreated |
2007-10-24
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pubmed:abstractText |
Cell growth pathways are mediated through protein-glycan interactions including O-glycosylation. Investigation of these growth pathways can be carried out using appropriate inhibitors to identify stage-specific events. We have adopted this approach to study a group of benzyl-O-N-acetyl-D-galactosamine analogues in human colorectal cancer cell lines. Exposure to O-glycan inhibitors resulted in the induction of apoptosis, a block in proliferation, accumulation of intracellular aryl-glycans and changes in related genes as detected by gene array. Colorectal cancer cell lines susceptible to the inhibitors showed growth arrest with all compounds. However, a differential action of each inhibitor was detected in the pattern of genes affected and in the structure of aryl-glycans formed.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0300-5127
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1372-4
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pubmed:meshHeading |
pubmed-meshheading:17956354-Apoptosis,
pubmed-meshheading:17956354-Cell Line, Tumor,
pubmed-meshheading:17956354-Cell Proliferation,
pubmed-meshheading:17956354-Colorectal Neoplasms,
pubmed-meshheading:17956354-Glycosylation,
pubmed-meshheading:17956354-Humans,
pubmed-meshheading:17956354-Polysaccharides,
pubmed-meshheading:17956354-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines.
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pubmed:affiliation |
Mucin Research Group, Clinical Science@South Bristol, Bristol BS2 8HW, U.K.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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