Linked Life Data

17956326

Source:http://linkedlifedata.com/resource/pubmed/id/17956326

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 5
pubmed:dateCreated
2007-10-24
pubmed:abstractText
The purine nucleotide ATP mediates several distinct forms of sensory transduction in both the peripheral and central nervous systems. These processes share common mechanisms that involve the release of ATP to activate ionotropic P2X and/or metabotropic P2Y receptors. Extracellular ATP signalling plays an important role in ventilatory control, mediating both peripheral and central chemosensory transduction to changes in arterial levels of oxygen and carbon dioxide. New data also suggest that extracellular ATP may play an important role in mediating certain neurophysiological responses to systemic inflammation. Here, we propose the novel concept that both peripheral and central neurophysiological effects of ATP may contribute to alterations in ventilatory control during inflammatory pathophysiological states.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0300-5127
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1264-8
pubmed:dateRevised
2010-4-26
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing.
pubmed:affiliation
Department of Physiology, University College London, Gower Street, London WC1E 6BT, U.K. g.ackland@ucl.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't