Linked Life Data

17956316

Source:http://linkedlifedata.com/resource/pubmed/id/17956316

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 5
pubmed:dateCreated
2007-10-24
pubmed:abstractText
The IIS (insulin/IGF (insulin-like growth factor) signalling) cascade has an important role in regulating normal development and physiology, as evidenced by its effects in a host of major human diseases including cancer, Type 2 diabetes and neurodegeneration. Recently, it has become clear that multiple types of local nutrient-sensing mechanisms have an impact on cellular insulin-sensitivity through the downstream kinase TOR (target of rapamycin). In vivo analysis in flies has surprisingly highlighted PATs (proton-assisted amino acid transporters) as having a uniquely potent role in regulating IIS/TOR activity and growth, potentially via a novel signalling mechanism. Other molecules such as the heterodimeric amino acid transporter, CD98, which provides the principal route for cellular uptake of leucine, an amino acid implicated in regulating TOR, also appear to have important effects. As our understanding of how nutrient sensing has an impact on IIS/TOR increases, novel targets to modulate aberrant IIS in disease are likely to emerge, which could complement current strategies designed to block kinases in this pathway.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-10667913, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-11680826, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-12611592, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-12748860, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-12969331, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-15843412, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-16049009, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-16288294, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-16495927, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-16684541, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-16785324, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-17046229, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-17253963, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-17371599, http://linkedlifedata.com/resource/pubmed/commentcorrection/17956316-17488712
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0300-5127
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1215-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders?
pubmed:affiliation
Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't