Linked Life Data

17955477

Source:http://linkedlifedata.com/resource/pubmed/id/17955477

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-2-28
pubmed:abstractText
The region on chromosome 7q stands out as the region of suggestive linkage to aetiology of autism with the greatest concordance in many independent genome-wide scans. RELN and GRM8, the two genes selected in this study, are located within this region. The protein products of both genes are considered to play a pivotal role in the development of the central nervous system. In addition, biochemical and neuroanatomical data indicated that RELN and GRM8 genes are likely involved in the pathogenesis of autistic disorder. Therefore, both RELN and GRM8 genes are considered to be not only the positional but also the functional candidate genes to autism for association research. In this study, we genotyped 12 single nucleotide polymorphisms (SNPs) located within the RELN and GRM8 genes in 213 children with autistic spectrum disorder (ASD) and 160 controls. A significant genetic association between SNP2 (located in intron 59 of RELN) and ASD was observed, and the log-additive model was accepted as the best inheritance model fitting this data (OR: 0.72, 95% CI: 0.54-0.97, P = 0.03). Haplotype-specific association analysis revealed that the result was consistent with the individual SNP study; the combination of SNP1/SNP2/SNP3/SNP4 which are in strong linkage disequilibrium (LD) (D' > 0.75) showed significant association with ASD (P = 0.027). Neither the single SNP nor the haplotype analysis showed significant association between ASD and the markers of GRM8 gene. Hence, our study suggested the possible involvement of RELN gene in the susceptibility to ASD. Future replications are warranted before definitive conclusion can be drawn.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1552-485X
pubmed:author
pubmed:copyrightInfo
(c) 2007 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
147B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
194-200
pubmed:dateRevised
2008-5-21
pubmed:meshHeading
pubmed-meshheading:17955477-Autistic Disorder, pubmed-meshheading:17955477-Cell Adhesion Molecules, Neuronal, pubmed-meshheading:17955477-Child, pubmed-meshheading:17955477-Child, Preschool, pubmed-meshheading:17955477-China, pubmed-meshheading:17955477-Extracellular Matrix Proteins, pubmed-meshheading:17955477-Female, pubmed-meshheading:17955477-Genetic Predisposition to Disease, pubmed-meshheading:17955477-Genetics, Population, pubmed-meshheading:17955477-Haplotypes, pubmed-meshheading:17955477-Humans, pubmed-meshheading:17955477-Linkage Disequilibrium, pubmed-meshheading:17955477-Male, pubmed-meshheading:17955477-Nerve Tissue Proteins, pubmed-meshheading:17955477-Polymorphism, Single Nucleotide, pubmed-meshheading:17955477-Receptors, Metabotropic Glutamate, pubmed-meshheading:17955477-Serine Endopeptidases
pubmed:year
2008
pubmed:articleTitle
The association analysis of RELN and GRM8 genes with autistic spectrum disorder in Chinese Han population.
pubmed:affiliation
Department of Central Laboratory, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't