Source:http://linkedlifedata.com/resource/pubmed/id/17954522
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2007-12-21
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| pubmed:abstractText |
Surfactant protein D (SP-D) plays a role in innate immunity in the lung and is expressed at many other mucosal surfaces throughout the human body. In this study, we show that SP-D mRNA and protein are present in the murine female reproductive tract; i.e. in the vagina, cervix, uterus and oviduct. SP-D protein is primarily localized to epithelial cells lining the genital tract and is also present in secretory material within the lumen of the uterus and cervix. The levels of SP-D mRNA in the uterus vary by a factor of 10 during the estrous cycle with peak levels present at estrus and the lowest levels at diestrus. In contrast, SP-D mRNA levels in the lung do not change during the estrous cycle. Since SP-D is an innate host defense protein present in the mouse reproductive tract, we studied the influence of infection on SP-D levels in vivo. We found that Chlamydia muridarum infection caused an increase in the SP-D protein content of reproductive tract epithelial cells. These data are suggestive that SP-D may play a role in innate immunity in the female reproductive tract in vivo.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
1460-2407
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
863-8
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17954522-Animals,
pubmed-meshheading:17954522-Cervix Uteri,
pubmed-meshheading:17954522-Chlamydia Infections,
pubmed-meshheading:17954522-Chlamydia muridarum,
pubmed-meshheading:17954522-Epithelial Cells,
pubmed-meshheading:17954522-Female,
pubmed-meshheading:17954522-Gene Expression Regulation,
pubmed-meshheading:17954522-Genitalia, Female,
pubmed-meshheading:17954522-Immunity, Innate,
pubmed-meshheading:17954522-Immunoblotting,
pubmed-meshheading:17954522-Lung,
pubmed-meshheading:17954522-Mice,
pubmed-meshheading:17954522-Oviducts,
pubmed-meshheading:17954522-Pulmonary Surfactant-Associated Protein D,
pubmed-meshheading:17954522-RNA, Messenger,
pubmed-meshheading:17954522-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17954522-Uterus,
pubmed-meshheading:17954522-Vagina
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Regulation of surfactant protein D in the mouse female reproductive tract in vivo.
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| pubmed:affiliation |
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA. oberleyr@njc.org
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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