Linked Life Data

17954275

Source:http://linkedlifedata.com/resource/pubmed/id/17954275

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-10-23
pubmed:abstractText
Well-differentiated liposarcomas (WDL) are intermediate malignant, locally aggressive mesenchymal neoplasms. The cytogenetic hallmarks of WDL are supernumerary rings and giant marker chromosomes containing material mainly from chromosome arms 1q and especially 12q, but also occasionally from other chromosomes. WDL are typical examples of tumors that may become more aggressive with time. One would assume that additional genomic changes lie behind the acquisition of such a more dangerous phenotype, and yet very little is known about the putative, late-occurring genomic aberrations in recurrent WDL. We have undertaken a pairwise comparison of the genomic imbalances occurring in primary and recurrent WDL from the same patient. In one of the cases, the patient's final recurrence, which was 17 years after the primary tumor and showed more pronounced nuclear atypia, had seven additional genomic changes compared with what was found in the primary tumor. The findings illustrate that the phenotypic changes some WDL undergo with time may have a genomic correlate, and that a pathogenetic continuum exists between WDL and dedifferentiated, more malignant liposarcomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Pairwise comparison of genomic imbalances between primary and recurrent well differentiated liposarcomas.
pubmed:affiliation
Department of Medical Genetics, Rikshospitalet-Radiumhospitalet Medical Centre, Ullernchausseen 70, Montebello, Oslo, Norway. francesca.micci@labmed.uio.no
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't