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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0020094,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0285558,
umls-concept:C0538927,
umls-concept:C0812228,
umls-concept:C1516044,
umls-concept:C1705328,
umls-concept:C1705341,
umls-concept:C1879547,
umls-concept:C1882071
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-14
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pubmed:abstractText |
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative disease of very poor clinical prognosis associated with infection by the human T-cell leukemia virus type I (HTLV-I). Treatment of patients with ATLL using conventional chemotherapy has limited benefit because HTLV-I cells are refractory to most apoptosis-inducing agents. In this study, we report that Celecoxib induces cell death via the intrinsic mitochondrial pathway in HTLV-I transformed leukemia cells. Treatment with Celecoxib was associated with activation of Bax, decreased expression of Mcl-1, loss of the mitochondrial membrane potential and caspase-9-dependent apoptosis. These effects were independent from Bcl-2 and Bcl-xL. We also found that Celecoxib inhibited the Akt/GSK3 beta survival pathway in HTLV-I cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BCL2L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/celecoxib,
http://linkedlifedata.com/resource/pubmed/chemical/myeloid cell leukemia sequence 1...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1360-8185
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-40
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pubmed:dateRevised |
2010-9-17
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pubmed:meshHeading |
pubmed-meshheading:17952603-Apoptosis,
pubmed-meshheading:17952603-Cell Line, Transformed,
pubmed-meshheading:17952603-Cell Line, Tumor,
pubmed-meshheading:17952603-Cell Proliferation,
pubmed-meshheading:17952603-Cyclooxygenase Inhibitors,
pubmed-meshheading:17952603-Human T-lymphotropic virus 1,
pubmed-meshheading:17952603-Humans,
pubmed-meshheading:17952603-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:17952603-Mitochondria,
pubmed-meshheading:17952603-Neoplasm Proteins,
pubmed-meshheading:17952603-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17952603-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:17952603-Pyrazoles,
pubmed-meshheading:17952603-Sulfonamides,
pubmed-meshheading:17952603-bcl-2-Associated X Protein,
pubmed-meshheading:17952603-bcl-X Protein
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pubmed:year |
2008
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pubmed:articleTitle |
Celecoxib disrupts the canonical apoptotic network in HTLV-I cells through activation of Bax and inhibition of PKB/Akt.
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pubmed:affiliation |
Department of Microbiology, Immunology, and Molecular Genetics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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