| pubmed-article:17951971 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0037369 | lld:lifeskim |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0750572 | lld:lifeskim |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0050078 | lld:lifeskim |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0311404 | lld:lifeskim |
| pubmed-article:17951971 | lifeskim:mentions | umls-concept:C0046007 | lld:lifeskim |
| pubmed-article:17951971 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17951971 | pubmed:dateCreated | 2007-10-22 | lld:pubmed |
| pubmed-article:17951971 | pubmed:abstractText | Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between oxidative DNA damage and MBOCA exposure. In addition, we examined the effects of different confounders on the plasma level of 8-OHdG. We undertook a cross-sectional survey at four MBOCA-producing factories in Taiwan (158 subjects). Plasma 8-OHdG levels and urinary MBOCA concentrations were measured by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). Personal characteristics were collected by questionnaire. The workers were classified according to their job titles as exposed (n=57) or unexposed (n=101) groups as well as classified according to urinary MBOCA levels as high urinary MBOCA (>20 microg/g creatinine) (n=45) or low urinary MBOCA (n=108) groups. Neither the MBOCA-exposed workers nor the high urinary MBOCA workers had a significant increase in the mean plasma 8-OHdG level, even after adjustment for potential confounders. Age and gender were significantly positively correlated with plasma 8-OHdG levels. Smokers among high urinary MBOCA workers also had significantly higher 8-OHdG levels than non-smokers among high urinary MBOCA workers. Our study provides evidence that smoking rather than MBOCA exposure induces elevation of plasma 8-OHdG levels among workers exposed to MBOCA, indicating that oxidative DNA damage does not play an important role in the carcinogenic processes of MBOCA. | lld:pubmed |
| pubmed-article:17951971 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17951971 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951971 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17951971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951971 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17951971 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17951971 | pubmed:issn | 1341-9145 | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:WuKuen-YuhKY | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:LiouSaou-Hsin... | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:LohChing-HuiC... | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:ShihTung-Shen... | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:ChenHong-IHI | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:ChenMing-Fong... | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:ChengLi-Chuan... | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:SunChien-WenC... | lld:pubmed |
| pubmed-article:17951971 | pubmed:author | pubmed-author:HoShu-FenSF | lld:pubmed |
| pubmed-article:17951971 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17951971 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:17951971 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17951971 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17951971 | pubmed:pagination | 389-98 | lld:pubmed |
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| pubmed-article:17951971 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17951971 | pubmed:articleTitle | Oxidative DNA damage estimated by plasma 8-hydroxydeoxyguanosine (8-OHdG): influence of 4, 4'-methylenebis (2-chloroaniline) exposure and smoking. | lld:pubmed |
| pubmed-article:17951971 | pubmed:affiliation | Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taiwan. | lld:pubmed |
| pubmed-article:17951971 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17951971 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
